Cobalt Chromium Toxicity Resource Center

Are Women More Sensitive to Negative Side Effects of Hip Replacements?

Acetabular LiningResearch from 2017 indicates that a person’s sex may have some effect on the likelihood of that person suffering complications from total hip or knee replacement surgery. It is thought that an increased rate of hypersensitivity to the metals in joint implants could be to blame.

The study was published in The Journal of Bone & Joint Surgery. It states that among patients with unexplained pain following total joint replacement using metal-containing components, women are more likely than men to experience metal sensitization.

The study involved 2,613 patients from a variety of demographics. On average, test subjects were 62 years of age. A majority of them were women. Average time since total joint replacement clocked in at three years, with the majority under two years. On a scale of 1 to 10, women reported higher average pain at 6.8, compared to men’s 6.1.

Testing for Metal Sensitization

All patients involved in the study submitted to blood tests to examine immune cell sensitization to metals. The test involved, the lymphocyte transformation test, is used to determine whether a patient is experiencing hypersensitivity to a variety of metals, which can include cobalt, chromium or nickel – all common in the construction of total hip and knee replacement components.

The results of the blood tests showed that women experienced immune sensitization to metals at a rate of 49 percent, compared to 38 percent for men. In patients experiencing immune sensitization, the severity was found to be much higher in women.

If you are experiencing negative health effects that you believe may be the result of your metal hip or knee replacement, call Kershaw, Cook & Talley at (916) 520-6639 or fill out our online contact form.


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